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Melanoma (also called malignant melanoma or cutaneous melanoma) accounts for only about 4%
of all cases of skin cancer, but causes 79% of deaths from skin cancer. The American
Cancer Society predicts 47,700 new cases of melanoma will occur in the United States in
the year 2000.
It is well known that solar radiation leads to the development of skin cancers. When
sunlight penetrates the top layers of the skin, ultraviolet (UVA or UVB) radiation damages
the DNA inside skin cells.
The incidence of melanoma has increased over the past several decades from a 1:1,500
lifetime risk in 1935 to a 1:75 lifetime risk in 2000. While the cause of this is not
known, it is known that depletion of the ozone layer in the upper atmosphere has increased
the amount of damaging ultraviolet radiation that reaches the earth.
Prevention is the most important aspect of care. Education regarding protection from sun
exposure is the best method to prevent the development of skin cancers.
Once melanoma has developed, early detection and treatment are key to a successful
outcome. Melanoma is almost always curable in its early stages.
Treatment may include a combination of Surgery, Chemotherapy, Chemotherapeutic Regional
Perfusion, Radiation Therapy, Immunotherapy, and Chemoimmunotherapy.
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This MediFocus Guide contains an extensive listing of citations and abstracts of
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other health care professionals. A partial selection of journal articles that are
abstracted in this MediFocus Guide includes:
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